منابع مشابه
Thymus-derived (t) Cell Immunoglobulins
Quantitation of surface and total cell Ig obtained after lysis by detergent, urea-acid treatment, and freeze-thawing were determined on spleen cells, thymus cells, and spleen cells specifically depleted of B cells. A two- to four-fold increase in measurable Ig was found after cell lysis. All cell populations showed a similar increase in measurable Ig indicating that no discordantly large amount...
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Due to the multiplicity of standards and complex rules; maintenance, repair and servicing of machinery could be done only by the fully qualified and proficient experts. Since the knowledge of such experts is not available all times, using expert systems can help to improve the maintenance process. To address this need and the uncertainty of the maintenance process indicators, this research prop...
متن کاملNegative Selection in the Thymus Includes Semimature T Cells
The thymic medulla plays a key role in negative selection (self-tolerance induction) and contains differentiated T cells en route to the extrathymic environment. However, being relatively mature, medullary T cells are thought to be beyond the stage of tolerance induction. This paradox is resolved by the finding that medullary T cells (CD4+8- thymocytes) comprise two distinct subsets. Medullary ...
متن کاملThymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction.
Using hen egg-white lysozyme, the effect of blood proteins on CD4 thymic cells was examined. A small fraction of i.v. injected hen egg-white lysozyme rapidly entered the thymus into the medulla. There it was captured and presented by dendritic cells (DCs) to thymocytes from two TCR transgenic mice, one directed to a dominant peptide and a second to a poorly displayed peptide, both presented by ...
متن کاملPeripheral Selection of T Cell Repertoires: The Role of Continuous Thymus Output
We investigated the role of continuous thymus output in the shaping of mature T cell repertoires by studying in vivo the survival of a single clone of mature Rag2-deficient T cell receptor (TCR) transgenic cells at different stages of activation in the absence or presence of thymus export. In the absence of thymus export, TCR-transgenic lymphocytes survived indefinitely in the peripheral pools....
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ژورنال
عنوان ژورنال: International Immunology
سال: 2018
ISSN: 1460-2377
DOI: 10.1093/intimm/dxy081